The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.

@article{Maclean2011TheRH,
  title={The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.},
  author={James A Maclean and Anilkumar Bettegowda and Byung Ju Kim and Chih-Hong Lou and Seung-Min Yang and Anjana Bhardwaj and Sreenath Shanker and Zhiying Hu and Yuhong Fan and Sigrid Eckardt and K J Mclaughlin and Arthur I. Skoultchi and Miles F. Wilkinson},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 6},
  pages={1275-87}
}
Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression is poorly understood. Here, we report that a major target of H1-mediated regulation in embryonic stem (ES) cells is the X-linked Rhox homeobox gene cluster. To address the underlying mechanism, we examined the founding member of the Rhox gene cluster-Rhox5-and found that its distal promoter (Pd) loses H1, undergoes demethylation, and is transcriptionally activated in response to loss… CONTINUE READING
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