The rhomboid-like superfamily: molecular mechanisms and biological roles.

@article{Freeman2014TheRS,
  title={The rhomboid-like superfamily: molecular mechanisms and biological roles.},
  author={Matthew Freeman},
  journal={Annual review of cell and developmental biology},
  year={2014},
  volume={30},
  pages={
          235-54
        }
}
  • M. Freeman
  • Published 6 October 2014
  • Biology
  • Annual review of cell and developmental biology
The rhomboid proteases were first discovered as regulators of Drosophila EGF receptor signaling; soon after, it was recognized that they represented the founder members of a widespread family of intramembrane serine proteases conserved in all kingdoms. More recently still, the family was promoted to a superfamily, encompassing a wide variety of distantly related proteins. One of the surprises has been that many members of the rhomboid-like superfamily are not active proteases. Given the size of… 

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