The rhodopsin–guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling

@article{Scheib2015TheRC,
  title={The rhodopsin–guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling},
  author={Ulrike Scheib and Katja Stehfest and Christine Elizabeth Gee and Heinz G K{\"o}rschen and Roman Fudim and Thomas G. Oertner and Peter Hegemann},
  journal={Science Signaling},
  year={2015},
  volume={8},
  pages={rs8 - rs8}
}
A light-responsive fungal guanylyl cyclase provides a tool with which to study cGMP signaling in mammalian systems. Lighting up cGMP signaling The second messenger cyclic guanosine monophosphate (cGMP) alters ion channel activity to mediate processes such as smooth muscle relaxation, transduction of light, and apoptosis. Guanylyl cyclases produce cGMP from GTP. Scheib et al. characterized the fungal photoreceptor RhGC, which consists of the light-sensitive receptor rhodopsin connected to a… Expand
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TLDR
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