The revolutionary developmental biology of Wilhelm His, Sr.

@article{Richardson2022TheRD,
  title={The revolutionary developmental biology of Wilhelm His, Sr.},
  author={Michael K. Richardson and Gerhard Keuck},
  journal={Biological Reviews},
  year={2022},
  volume={97}
}
Swiss‐born embryologist Wilhelm His, Sr. (1831–1904) was the first scientist to study embryos using paraffin histology, serial sectioning and three‐dimensional modelling. With these techniques, His made many important discoveries in vertebrate embryology and developmental neurobiology, earning him two Nobel Prize nominations. He also developed several theories of mechanical and evolutionary developmental biology. His argued that adult form is determined by the differential growth of… 
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2 Citations

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Citation Type

Theories, laws, and models in evo-devo.
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  • 2021
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It is argued that the "body plan" is an archetype, and is often used in such a way that it lacks any scientific meaning, and one challenge for evo-devo will be to develop new theories and models to accommodate the wealth of new data from high-throughput sequencing, as in the "transcriptomic hourglass" models.
Essay the (unusual) heuristic value of Hox gene clusters; a matter of time?

References

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TLDR
A series of essays highlighting problems and achievements in developmental biology in the discipline's early years is initiated, encouraged by the increasing interest taken by practising developmental biologists in various countries in the history of their discipline and in the views of its pioneers.
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TLDR
Leading developmental biology textbooks tell their readers that a new field of experimental embryology emerged somewhere around the end of the nineteenth or the beginning of the twentieth century, with the work of Wilhelm Roux on Entwicklungsmechanik (or developmental mechanics).
Historical perspective on neuroembryology: Wilhelm His and his contemporaries
TLDR
The article places His’ work in the scientific context of 19th century embryology, concerned with reconciling the embryonic layers theory, the cell theory and the evolution theory, at the junction of two embryological traditions, the descriptive morphological approach and the new experimental approach.
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TLDR
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TLDR
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TLDR
Recovering the wax models made by the anatomist Wilhelm His in the late 1860s offers a fresh perspective on the transformation of a central science of animal life and enriches the understanding of the relations between representation in two dimensions and three.
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TLDR
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Wilhelm His and mechanistic approaches to development at the time of Entwicklungsmechanik
TLDR
It appears that Wilhelm His first succeeded in combining the question of the causal factors determining epigenesis, which was closely connected with experimentation on, and cellular descriptions of, development, in a coherent and concrete synthesis, making him one of the true initiators of the developmental mechanics.
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TLDR
His lab was the first to describe nested patterns of Hox gene expression in the developing mouse limb, and later showed that digit-associated Hoxd gene expression was lacking in zebrafish paired fin development and helped reveal that the genital tubercle may be patterned by Hox genes.
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