The revolutionary developmental biology of Wilhelm His, Sr.
@article{Richardson2022TheRD, title={The revolutionary developmental biology of Wilhelm His, Sr.}, author={Michael K. Richardson and Gerhard Keuck}, journal={Biological Reviews of the Cambridge Philosophical Society}, year={2022}, volume={97}, pages={1131 - 1160} }
Swiss‐born embryologist Wilhelm His, Sr. (1831–1904) was the first scientist to study embryos using paraffin histology, serial sectioning and three‐dimensional modelling. With these techniques, His made many important discoveries in vertebrate embryology and developmental neurobiology, earning him two Nobel Prize nominations. He also developed several theories of mechanical and evolutionary developmental biology. His argued that adult form is determined by the differential growth of…
2 Citations
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References
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Leading developmental biology textbooks tell their readers that a new field of experimental embryology emerged somewhere around the end of the nineteenth or the beginning of the twentieth century, with the work of Wilhelm Roux on Entwicklungsmechanik (or developmental mechanics).
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It appears that Wilhelm His first succeeded in combining the question of the causal factors determining epigenesis, which was closely connected with experimentation on, and cellular descriptions of, development, in a coherent and concrete synthesis, making him one of the true initiators of the developmental mechanics.
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