The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.

@article{Shaw1985TheRC,
  title={The reversible cholinesterase inhibitor physostigmine has channel-blocking and agonist effects on the acetylcholine receptor-ion channel complex.},
  author={K P Shaw and Yasco Aracava and Akinori Akaike and John W. Daly and D. Rickett and Edson X. Albuquerque},
  journal={Molecular pharmacology},
  year={1985},
  volume={28 6},
  pages={527-38}
}
The actions of the carbamate cholinesterase inhibitors, physostigmine (Phy) and physostigmine methiodide (MetPhy), were studied on the acetylcholine receptor-ion channel complex (AChR) of skeletal muscles. Low concentrations of these agents produced cholinesterase inhibition which resulted in potentiation of nerve-elicited muscle twitches and an increased peak amplitude and prolongation of the decay time constant (tau EPC) of endplate currents (EPCs) elicited in frog (Rana pipiens) sartorius… CONTINUE READING
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