The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention

@article{TarragoLitvak1994TheRT,
  title={The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention},
  author={L. Tarrago-Litvak and M. Andr{\'e}ola and G. Nevinsky and L. Sarih-Cottin and S. Litvak},
  journal={The FASEB Journal},
  year={1994},
  volume={8},
  pages={497 - 503}
}
  • L. Tarrago-Litvak, M. Andréola, +2 authors S. Litvak
  • Published 1994
  • Biology, Medicine
  • The FASEB Journal
  • The human immunodeficiency virus type 1 (HIV‐1) is the etiologic agent of AIDS. Replication of this virus requires the activity of a retrovirus encoded RNA‐dependent DNA polymerase, or reverse transcriptase (RT). HIV‐1 RT is required for the synthesis of the double‐stranded proviral DNA from the single‐stranded retroviral RNA genome. HIV‐1 RT has two subunits of 66 kDa and 51 kDa. The 66‐kDa subunit contains the DNA polymerase and RNase H domains whereas the 51‐kDa subunit, obtained by… CONTINUE READING
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