The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention

@article{TarragoLitvak1994TheRT,
  title={The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention},
  author={L. Tarrago-Litvak and M. Andr{\'e}ola and G. Nevinsky and L. Sarih-Cottin and S. Litvak},
  journal={The FASEB Journal},
  year={1994},
  volume={8},
  pages={497 - 503}
}
  • L. Tarrago-Litvak, M. Andréola, +2 authors S. Litvak
  • Published 1994
  • Biology, Medicine
  • The FASEB Journal
    • The human immunodeficiency virus type 1 (HIV‐1) is the etiologic agent of AIDS. Replication of this virus requires the activity of a retrovirus encoded RNA‐dependent DNA polymerase, or reverse transcriptase (RT). HIV‐1 RT is required for the synthesis of the double‐stranded proviral DNA from the single‐stranded retroviral RNA genome. HIV‐1 RT has two subunits of 66 kDa and 51 kDa. The 66‐kDa subunit contains the DNA polymerase and RNase H domains whereas the 51‐kDa subunit, obtained by… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    23 Citations
    Background Citations
    8
    Methods Citations
    1
    23 Citations
    Citation Type

    Citation Type

    Phosphorothioate oligonucleotides derived from human immunodeficiency virus type 1 (HIV-1) primer tRNALys3 are strong inhibitors of HIV-1 reverse transcriptase and arrest viral replication in infected cells.
    • 13
    • PDF
    Interaction of human immunodeficiency virus type 1 reverse transcriptase with primer tRNALys3 and affinity modification of the enzyme by tRNALys3 derivatives.
    • 3
    Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions
    • 13
    High-affinity interaction of human immunodeficiency virus type-1 reverse transcriptase with partially complementary primers.
    • 4
    Immunogenic properties of reverse transcriptase of HIV type 1 assessed by DNA and protein immunization of rabbits.
    • 13
    Interaction of HIV-1 Reverse Transcriptase with New Minor Groove Binders and Their Conjugates with Oligonucleotides
    • 3
    Core Structure of gp41 from the HIV Envelope Glycoprotein
    • 1,250
    • PDF
    Cellular reservoirs of HIV-1 and their role in viral persistence.
    • 304
    A neutravidin-based assay for reverse transcriptase suitable for high throughput screening of retroviral activity.
    • 2
    • PDF
    Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.
    • 35
    • PDF

    References

    SHOWING 1-10 OF 92 REFERENCES
    HIV‐1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
    • 243
    Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations
    • 146
    HIV reverse transcriptase structure-function relationships.
    • 155
    Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding.
    • 39
    Review of HIV-1 reverse transcriptase three-dimensional structure : implications for drug design
    • 114
    Interaction of tRNALys with the p66/p66 form of HIV-1 reverse transcriptase stimulates DNA polymerase and ribonuclease H activities.
    • 26
    Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.
    • N. Tanese, S. Goff
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1988
    • 152
    • PDF
    Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase.
    • 444
    Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.
    • 56
    • PDF
    6 Roles of Ribonuclease H in Reverse Transcription
    • 73