The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention

  title={The reverse transcriptase of HIV‐1: from enzymology to therapeutic intervention},
  author={L. Tarrago-Litvak and M. Andr{\'e}ola and G. Nevinsky and L. Sarih-Cottin and S. Litvak},
  journal={The FASEB Journal},
  pages={497 - 503}
  • L. Tarrago-Litvak, M. Andréola, +2 authors S. Litvak
  • Published 1994
  • Biology, Medicine
  • The FASEB Journal
  • The human immunodeficiency virus type 1 (HIV‐1) is the etiologic agent of AIDS. Replication of this virus requires the activity of a retrovirus encoded RNA‐dependent DNA polymerase, or reverse transcriptase (RT). HIV‐1 RT is required for the synthesis of the double‐stranded proviral DNA from the single‐stranded retroviral RNA genome. HIV‐1 RT has two subunits of 66 kDa and 51 kDa. The 66‐kDa subunit contains the DNA polymerase and RNase H domains whereas the 51‐kDa subunit, obtained by… CONTINUE READING
    23 Citations
    Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions
    • 13
    Interaction of HIV-1 Reverse Transcriptase with New Minor Groove Binders and Their Conjugates with Oligonucleotides
    • 3
    Core Structure of gp41 from the HIV Envelope Glycoprotein
    • 1,250
    • PDF
    Cellular reservoirs of HIV-1 and their role in viral persistence.
    • 304
    A neutravidin-based assay for reverse transcriptase suitable for high throughput screening of retroviral activity.
    • 2
    • PDF


    HIV reverse transcriptase structure-function relationships.
    • 155
    Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.
    • N. Tanese, S. Goff
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1988
    • 152
    • PDF
    Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.
    • 56
    • PDF