The reverse transcriptase–RNase H: from viruses to antiviral defense

@article{Moelling2015TheRT,
  title={The reverse transcriptase–RNase H: from viruses to antiviral defense},
  author={Karin Moelling and Felix Broecker},
  journal={Annals of the New York Academy of Sciences},
  year={2015},
  volume={1341}
}
Ubiquitous, reverse transcriptase may have contributed to the transition from the RNA to the DNA world, a transition that also involved RNase H–like activities. Both enzymes shaped various genomes and antiviral defense systems as endogenous retroviruses (ERVs) and transposable elements (TEs). A close relationship between a dozen components of retroviruses and the small interfering RNA (siRNA) antiviral‐defense machinery has been characterized. Most antiviral‐defense systems involve RNase H–like… Expand
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