• Biology, Medicine
  • Published in Journal of virology 1989

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region.

@article{HadzopoulouCladaras1989TheR,
  title={The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region.},
  author={Margarita Hadzopoulou-Cladaras and Barbara K Felber and C Cladaras and Anastasios Athanassopoulos and Allan H.L. Tse and George N Pavlakis},
  journal={Journal of virology},
  year={1989},
  volume={63 3},
  pages={
          1265-74
        }
}
The study of expression of several human immunodeficiency virus type 1 proviral mutants in human cells in the presence or absence of rev (trs/art) protein reveals that rev increases the levels of unspliced and env mRNA and the accumulated structural viral proteins. rev protein produced from appropriate expression vectors fully complements the rev-defective mutants. rev requires the presence of a specific cis-acting sequence for its function. This rev-responsive element sequence has been… CONTINUE READING

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