The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

  title={The return of metabolism: biochemistry and physiology of the pentose phosphate pathway},
  author={Anna Stincone and Alessandro Prigione and Thorsten Cramer and Mirjam M. C. Wamelink and Kate Campbell and Eric C. C. Cheung and Viridiana Ol{\'i}n-Sandoval and Nana-Maria Gr{\"u}ning and Antje Kr{\"u}ger and Mohammad Tauqeer Alam and Markus A Keller and Michael Breitenbach and Kevin M Brindle and Joshua D. Rabinowitz and Markus Ralser},
  booktitle={Biological reviews of the Cambridge Philosophical Society},
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism, and to defeat oxidative stress. The PPP shares reactions with the Entner-Doudoroff pathway and Calvin cycle and divides into an oxidative and non-oxidative branch. The oxidative branch is highly active in most eukaryotes and converts glucose 6… CONTINUE READING
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