The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.

@article{Kim2005TheRA,
  title={The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.},
  author={Hanna Y. Kim and Jacques Lapointe and Gulsah Kaygusuz and David E. Ong and C Li and Matt van de Rijn and James D Brooks and Jonathan R. Pollack},
  journal={Cancer research},
  year={2005},
  volume={65 18},
  pages={8118-24}
}
Prostate cancer is the most common cancer among men in the United States, and aberrant DNA methylation is known to be an early molecular event in its development. Here, we have used expression profiling to identify novel hypermethylated genes whose expression is induced by treatment of prostate cancer cell lines with the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-aza-dC). Of the 271 genes that were induced by 5-aza-dC treatment, 25 also displayed reduced expression in primary… CONTINUE READING

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Molecular genetics of human prostate cancer

  • MA Rubin, AM DeMarzo
  • Mod Pathol
  • 2004

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