The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.

@article{Romand2002TheRA,
  title={The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.},
  author={Raymond Romand and Eri Hashino and Pascal Doll{\'e} and Jean-Luc Vonesch and Pierre Chambon and Norbert B. Ghyselinck},
  journal={Mechanisms of development},
  year={2002},
  volume={119 2},
  pages={213-23}
}
To define the signal transduction pathway of retinoic acid during inner ear development, we analyzed the expression patterns of transcripts encoding the three retinoic acid receptors (RARalpha, beta, and gamma) and related them to phenotypes resulting from single or compound inactivation of these nuclear receptors. The expression of all three RARs was observed in the developing mouse otocyst as early as embryonic day 10.5 (E10.5)-E12.5 and continued into adulthood. Expression domains of the… CONTINUE READING