The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.

@article{AbuAbed2001TheRA,
  title={The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.},
  author={Suzan S. Abu-Abed and Pascal Doll{\'e} and Daniel Metzger and Barbara R. Beckett and Pierre Chambon and M. Petkovich},
  journal={Genes & development},
  year={2001},
  volume={15 2},
  pages={226-40}
}
The active derivative of vitamin A, retinoic acid (RA), is essential for normal embryonic development. The spatio-temporal distribution of embryonic RA results from regulated expression of RA-synthesizing retinaldehyde dehydrogenases and RA-metabolizing cytochrome P450s (CYP26). Excess RA administration or RA deficiency results in a complex spectrum of embryonic abnormalities. As a first step in understanding the developmental function of RA-metabolizing enzymes, we have disrupted the murine… CONTINUE READING
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