The retinoblastoma tumour suppressor in development and cancer

@article{Classon2002TheRT,
  title={The retinoblastoma tumour suppressor in development and cancer},
  author={Marie Classon and Ed Harlow},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={910-917}
}
Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique… Expand

Figures, Tables, and Topics from this paper

Retinoblastoma Tumor Suppressor Gene
TLDR
The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be identified and possesses many functions that impinge on cell proliferation and fate decisions, cell viability, and genome integrity. Expand
Cellular mechanisms of tumour suppression by the retinoblastoma gene
The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range of paediatric and adult cancers, and a plethora of cellular functions and partners have been identified forExpand
Tailoring to RB: tumour suppressor status and therapeutic response
TLDR
The retinoblastoma tumour suppressor is a crucial regulator of cell-cycle progression that is invoked in response to a myriad of anti-mitogenic signals and its status may be particularly informative in directing treatment regimens. Expand
The retinoblastoma protein--from bench to bedside.
  • S. Mittnacht
  • Biology, Medicine
  • European journal of cell biology
  • 2005
TLDR
Mouse models with engineered defects in the Rb-phosphorylating kinases provide evidence that moderation of Rb inactivation may be a strategy for the prevention of tumour formation. Expand
The search for the retinoblastoma cell of origin
TLDR
Retinoblastoma, a rare childhood cancer of the retina that is caused by RB inactivation, is a good model in which to search for a tumour cell of origin, because retinal development is well understood and the initiating genetic lesion is well characterized. Expand
The Retinoblastoma Tumour Suppressor
TLDR
Which functions of pRB contribute most to its tumour-suppressor activity are determined, why certain tumours select against RB but others do not, and what kind of additional mutations are likely to cooperate with RB loss in cancer as a function of tissue type are discussed. Expand
Regulation of cell lineage specification by the retinoblastoma tumor suppressor
TLDR
This work reviews recent studies uncovering novel mechanisms by which the retinoblastoma gene works in several cell lineages and provides perspectives on how these new findings might relate to RB tumor suppression. Expand
Dysfunction of the RB Retinoblastoma Gene in Cancer
TLDR
Emerging evidence shows that RB status can influence the response to different anti-cancer therapeutics according to the context, suggesting that a thorough understanding of all RB functions in cancer is more crucial than ever. Expand
Retinoblastoma and tumor-suppressor gene therapy.
  • Hongji Xu
  • Medicine
  • Ophthalmology clinics of North America
  • 2003
TLDR
Reconstitution of RB function in RB-deficient tumor cells induces irreversible growth arrest and inhibits telomerase activity, simultaneously correcting two of the four defined carcinogenic events in human cells. Expand
Role of the retinoblastoma tumor suppressor protein in cellular differentiation
TLDR
The increasing evidence for a role of pRb105 in cellular differentiation and the fact that various cancers, which contain mutant pR b105, or mutations in proteins in the pRB105 pathway, are perhaps a result of deregulation of differentiation are discussed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 158 REFERENCES
The retinoblastoma gene family in differentiation and development
The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new roleExpand
The retinoblastoma gene family: cousins with overlapping interests.
TLDR
Here, studies of RB1 gene family function are reviewed, with emphasis on in vivo experiments that explore shared and distinct functions within this family. Expand
Effects of an Rb mutation in the mouse
TLDR
A mouse strain has been constructed in which one allele of Rb is disrupted, and heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Expand
Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.
TLDR
This demonstration of suppression of the neoplastic phenotype by a single gene provides direct evidence for an essential role of the RB gene in tumorigenesis. Expand
Retinoblastoma protein partners.
TLDR
The goal of this review is to summarize the current literature of pRb-associated proteins and to raise several important questions, including how many functions does pRB possess, which of these functions are important for development, and which contribute to tumor suppression. Expand
The role of p53 and pRB in apoptosis and cancer.
TLDR
The pRB and p53 pathways regulate apoptosis and thus the development of tumours and in the past two years, mouse genetics and gene expression profiling have led to major advances in understanding of how this pathway regulates apoptosis. Expand
Cooperative tumorigenic effects of germline mutations in Rb and p53
TLDR
The phenotypic effects of combined germline mutations in these two tumour suppressor genes Rb and p53 are described to indicate that mutations in Rband p53 can cooperate in the transformation of certain cell types in the mouse. Expand
Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis.
  • H. Yamamoto, J. Soh, +8 authors I. Weinstein
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1999
TLDR
The findings suggest that the increased expression of pRb in colorectal carcinoma cells may provide a homeostatic mechanism that protects them from growth inhibition and apoptosis, perhaps by counterbalancing potentially toxic effects of excessive E2F activity. Expand
Retinoblastoma protein meets chromatin.
TLDR
Findings point towards a link between chromatin regulation and cancer. Expand
Retinoblastoma in transgenic mice
TLDR
It is reported that expression of a viral oncogene, the simian virus 40 T antigen, in the retina of transgenic mice produces heritable ocular tumours with histological, ultrastructural and immunohis-tochemical features identical to those of human retinoblastoma. Expand
...
1
2
3
4
5
...