The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death

@article{Knudsen1999TheRT,
  title={The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death},
  author={Karen E. Knudsen and Erich C. Weber and Karen C. Arden and Webster K Cavenee and James R. Feramisco and Erik S. Knudsen},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={5239-5245}
}
Studies aimed at examining the precise function(s) of the retinoblastoma tumor suppressor protein, RB, have been hindered by the rapid phosphorylation and inactivation of ectopically expressed RB which occurs in the majority of cell types. Therefore, ectopically expressed RB is a poor inhibitor of cellular proliferation. We have designed constitutively active RB proteins, PSM-RB, that cannot be inactivated by phosphorylation. Using these proteins, we show that unlike wild-type RB, PSM-RB… CONTINUE READING

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