The retinoblastoma protein physically associates with the human cdc2 kinase.

@article{Hu1992TheRP,
  title={The retinoblastoma protein physically associates with the human cdc2 kinase.},
  author={Quingmin J. Hu and Jacqueline A Lees and Karen J. Buchkovich and E E Harlow},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 3},
  pages={971-80}
}
The protein product (pRB) of the retinoblastoma susceptibility gene functions as a negative regulator of cell proliferation, and its activity appears to be modulated by phosphorylation. Using a new panel of anti-human pRB monoclonal antibodies, we have investigated the biochemical properties of this protein. These antibodies have allowed us to detect a pRB-associated kinase that has been identified as the cell cycle-regulating kinase p34cdc2 or a closely related enzyme. Since this associated… CONTINUE READING