The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.

@article{Fromm1994TheRP,
  title={The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice.},
  author={Laurie Fromm and William Shawlot and Karen M Gunning and Janet S Butel and Paul Overbeek},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 10},
  pages={
          6743-54
        }
}
Regulation of the cell cycle is a critical aspect of cellular proliferation, differentiation, and transformation. In many cell types, the differentiation process is accompanied by a loss of proliferative capability, so that terminally differentiated cells become postmitotic and no longer progress through the cell cycle. In the experiments described here, the ocular lens has been used as a system to examine the role of the retinoblastoma protein (pRb) family in regulation of the cell cycle… CONTINUE READING
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