The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis.

@article{Herwig1997TheRP,
  title={The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis.},
  author={Susanne Herwig and Michael Strauss},
  journal={European journal of biochemistry},
  year={1997},
  volume={246 3},
  pages={581-601}
}
The retinoblastoma susceptibility gene is a tumour suppressor and its product retinoblastoma protein (pRb) has been known for 10 years as a repressor of progression towards S phase. Its major activity was supposed to be sequestration or inactivation of the transcription factor E2F which is required for activation of S phase genes. However, within recent years growing evidence has been accumulating for a more general function of pRb at both the transcriptional level and the cellular level. pRb… CONTINUE READING

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