The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.

@article{Savoysky1994TheRB,
  title={The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.},
  author={E Savoysky and Takayuki Mizuno and Yoshihiro Sowa and Hirotaka Watanabe and Jun-ichi Sawada and Hitoshi Nomura and Yohta Ohsugi and Hiroshi Handa and Tetsuo Sakai},
  journal={Oncogene},
  year={1994},
  volume={9 7},
  pages={1839-46}
}
The tumor suppressor retinoblastoma gene product, pRB, is a well known regulator of G1/S cell cycle progression. Moreover, mutational inactivations within the retinoblastoma gene (RB) are found in many human malignant tumors, and thus, believed to be an essential step in tumor formation. The human RB gene is considered as a housekeeping gene with no characteristic TATA or CAAT elements in its promoter region, but the sequence between 206 and 185 bases upstream of the initiation codon, essential… CONTINUE READING