The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.

@article{Linari1999TheRP,
  title={The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.},
  author={Marco Linari and Marius Ueffing and Forbes D Manson and Andrew N. Wright and Thomas Meitinger and J{\"o}rg Becker},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 4},
  pages={1315-20}
}
Recently, the retinitis pigmentosa 3 (RP3) gene has been cloned and named retinitis pigmentosa GTPase regulator (RPGR). The amino-terminal half of RPGR is homologous to regulator of chromosome condensation (RCC1), the nucleotide exchange factor for the small GTP-binding protein Ran. In a yeast two-hybrid screen we identified the delta subunit of rod cyclic GMP phosphodiesterase (PDEdelta) as interacting with the RCC1-like domain (RLD) of RPGR (RPGR392). The interaction of RPGR with PDEdelta was… CONTINUE READING