The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.

@article{Billings2013TheRR,
  title={The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.},
  author={Sara E Billings and Keely Pierzchalski and Naomi E Butler Tjaden and Xiao-Yan Pang and Paul A Trainor and Maureen A. Kane and Alexander R Moise},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 12},
  pages={4877-89}
}
Oxidation of retinol via retinaldehyde results in the formation of the essential morphogen all-trans-retinoic acid (ATRA). Previous studies have identified critical roles in the regulation of embryonic ATRA levels for retinol, retinaldehyde, and ATRA-oxidizing enzymes; however, the contribution of retinaldehyde reductases to ATRA metabolism is not completely understood. Herein, we investigate the role of the retinaldehyde reductase Dhrs3 in embryonic retinoid metabolism using a Dhrs3-deficient… CONTINUE READING

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