The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.

@article{Weindruch1986TheRO,
  title={The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.},
  author={R. Weindruch and R. Walford and S. Fligiel and D. Guthrie},
  journal={The Journal of nutrition},
  year={1986},
  volume={116 4},
  pages={
          641-54
        }
}
We sought to clarify the impact of dietary restriction (undernutrition without malnutrition) on aging. Female mice from a long-lived strain were fed after weaning in one of six ways: group 1) a nonpurified diet ad libitum; 2) 85 kcal/wk of a purified diet (approximately 25% restriction); 3) 50 kcal/wk of a restricted purified diet enriched in protein, vitamin and mineral content to provide nearly equal intakes of these essentials as in group 2 (approximately 55% restriction); 4) as per group 3… Expand
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