The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas.

@article{Cetta1998TheRO,
  title={The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas.},
  author={Francesco Cetta and Gennaro Chiappetta and Rosa Marina Melillo and Margherita Petracci and Giulia Montalto and Massimo Santoro and Alfredo Fusco},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1998},
  volume={83 3},
  pages={1003-6}
}
Familial adenomatous polyposis (FAP) is caused by germ-line mutations of the apc gene, and it is associated with an increased risk of developing papillary thyroid carcinomas. We have previously reported that a significant fraction of sporadic human papillary thyroid carcinomas is characterized by gene rearrangements affecting the ret protooncogene. These rearrangements generate chimeric transforming oncogenes designated ret/ptc. By a combined immunohistochemical and RT-PCR approach, we analyzed… CONTINUE READING
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Germ-line APC mutations in patients with familial adenomatous polyposis associated thyroid carcinoma. Results from a European collaborative study

  • F Cetta, M Petracci, G Montalto
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Progression of tumorigenesis in patients with papillary carcinoma of the thyroid associated with familial ademomatous polyposis

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