The restless legs syndrome

@article{Barrire2005TheRL,
  title={The restless legs syndrome},
  author={Gr{\'e}gory Barri{\`e}re and Jean-Ren{\'e} Cazalets and Bernard H. Bioulac and Francois Tison and Imad Ghorayeb},
  journal={Progress in Neurobiology},
  year={2005},
  volume={77},
  pages={139-165}
}
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39 Citations
Highly Influential Citations
1
Background Citations
10
Methods Citations
1

39 Citations

Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management
TLDR
Augmentation is very common in long-term treatment of RLS which makes prevention and management of augmentation very important for RLS patients, and a combination of different types of medication is effective in preventing and treating augmentation.
Cannabis for Restless Legs Syndrome.
  • I. Ghorayeb
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2021
TLDR
The antinociceptive effect of marijuana has been documented in many painful neurological conditions and the potential benefit of cannabis use in patients with refractory RLS should be questioned by robust clinical trials.
Restless legs syndrome and depression-anxiety disorder association in iron deficiency anemia patients
TLDR
The incidence of restless leg syndrome in anemic patients without any other organic disease or drug use, which can cause restless legs syndrome, is investigated and a significant difference was not found in Beck depression scores between patients with and without RLS.
Sensory symptoms in restless legs syndrome: the enigma of pain.
Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome
Restless legs syndrome: Clinical changes in nervous system excitability at the spinal cord level.
Association of restless legs syndrome variants in Korean patients with restless legs syndrome.
TLDR
The results suggest that the role of BTBD9 in the pathogenesis of restless legs syndrome is more universal across populations than previously reported and more efforts should be focused on the roleof epistasis in the genetic architecture of restless Legs syndrome.
Relationship between Restless legs syndrome associated symptoms and presence of depression during pregnancy
TLDR
It was concluded that RLS-associated symptoms may be indicators of depression during pregnancy and comprehensive sleep evaluations and examinations of RLS -associated symptoms are needed to improve psychiatric health during pregnancy.
Impaired Sensorimotor Integration in Restless Legs Syndrome
TLDR
The results suggest increased motor cortical excitability of the legs and disturbed sensorimotor integration in RLS patients; this disturbance might originate at the cortical level.
Circadian variation in restless legs syndrome.
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References

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New paradigms in the treatment of restless legs syndrome
TLDR
Clinicians must be aware of the high prevalence of RLS, the potential for onset before age 20, and the various clinical presentations, and rely on dopamine agonists first-line therapy and provide symptom relief in 70% to 100% of patients.
Toward a better definition of the restless legs syndrome
TLDR
Features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance.
Restless legs syndrome in patients on dialysis.
TLDR
Treatment in uremic RLS should involve the reduction of potential exacerbating agents, correction of anemia (with erythropoietin and iron), and use of levodopa or dopamine agonists.
The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization
  • W. Hening
  • Medicine
    Clinical Neurophysiology
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Restless legs syndrome
TLDR
There are two major etiologic subgroups of RLS but that the two share central pathophysiologic mechanisms, and it is concluded that Levodopa and dopamine agonists were the most effective treatments.
Genetics in restless legs syndrome.
Dopamine and iron in the pathophysiology of restless legs syndrome (RLS).
Restless legs syndrome
TLDR
Restless legs syndrome is a common cause of insomnia related to problems with sleep initiation and sleep maintenance, unrefreshing sleep, and excessive daytime sleepiness, and it may signify an underlying medical condition.
Restless legs syndrome in Parkinson's disease
Restless legs syndrome in childhood and adolescence.
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