The response to sulpiride in social anxiety disorder: D2 receptor function

@article{Bell2013TheRT,
  title={The response to sulpiride in social anxiety disorder: D2 receptor function},
  author={Caroline J Bell and Shamina Bhikha and Helen C. Colhoun and Frances A. Carter and Chris M Frampton and Richard J. Porter},
  journal={Journal of Psychopharmacology},
  year={2013},
  volume={27},
  pages={146 - 151}
}
Some previous studies have suggested that patients with social anxiety disorder (SAD) have a hypoactive central dopaminergic system. Supporting this there have been reports from neuroimaging studies of reduced striatal D2 receptor binding in subjects with SAD. The aim of this study was to investigate D2 receptor sensitivity in patients with SAD compared with a group of matched, healthy controls using a neuroendocrine challenge with the selective D2 antagonist, sulpiride. D2 receptor function… 
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References

SHOWING 1-10 OF 37 REFERENCES

The prolactin response to sulpiride in major depression: the role of the D2 receptor in depression

The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function

After 16 weeks of cognitive behavioural therapy (CBT), an enhanced prolactin response to sulpiride was detected, suggesting an increased sensitivity of D2 receptor functioning.

A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia

Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia.

The findings suggest that patients with social phobia may exhibit selective supersensitivity of serotonergic systems, but that dopaminergic and noradrenergic function appear normal.

Striatal dopamine D2 receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings

Comorbid GSAD and OCD may be associated with decreased availability of D2 receptors in the striatum, consistent with prior findings in GSAD.

Dopamine reuptake site densities in patients with social phobia.

blind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects.

Low dopamine D(2) receptor binding potential in social phobia.

Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum, and there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score.

Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.

Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets.

The emergence of social phobia during clozapine treatment and its response to fluoxetine augmentation.

Data is discussed in light of neurochemical mechanisms and cognitive adaptations that could explain the onset of anxiety spectrum disorders (such as social phobia) in clozapine-treated schizophrenic subjects during remission of psychotic symptoms.

Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson’s disease

All of the tasks impaired following sulpiride are known to be sensitive to frontal lobe damage and the precise pattern of deficits seen is consistent with the anatomical distribution of central dopamine receptors.