The response to sulpiride in social anxiety disorder: D2 receptor function

  title={The response to sulpiride in social anxiety disorder: D2 receptor function},
  author={Caroline J Bell and Shamina Bhikha and Helen C. Colhoun and Frances A. Carter and Chris M Frampton and Richard J. Porter},
  journal={Journal of Psychopharmacology},
  pages={146 - 151}
Some previous studies have suggested that patients with social anxiety disorder (SAD) have a hypoactive central dopaminergic system. Supporting this there have been reports from neuroimaging studies of reduced striatal D2 receptor binding in subjects with SAD. The aim of this study was to investigate D2 receptor sensitivity in patients with SAD compared with a group of matched, healthy controls using a neuroendocrine challenge with the selective D2 antagonist, sulpiride. D2 receptor function… 

Figures and Tables from this paper

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.

Oxytocin has a wide range of effects over neural activity in response to social and emotional processing, which is further modulated by sex and task specificity, and the magnitude of this neural activation is largest in the temporal lobes.

Anxiety Disorder, Depressive Symptoms and Sleep Quality During COVID-19

The paper presents the results of a survey of 1,736 respondents, residents of Bishkek, Kyrgyz Republic during the development of the COVID-19 epidemic, as well as the introduction of quarantine measures and a state of emergency, which showed that the lowest level of reactive anxiety is present in the age group of 36–45 years old, and personal anxiety — in the group of 24–36 years old and over 65 years old.

Trends and factors in antipsychotic use of outpatients with anxiety disorders in Taiwan, 2005–2013: A population‐based study

Examination of the trends and associated factors of antipsychotic use among outpatients with anxiety disorders in Taiwan during 2005–2013 found that antipsychotics off‐label use is common in clinical practice.

Examining the neural basis of decision-making using social stimuli, dopamine and oxytocin in schizophrenia

The present study focuses on the development of a modeling framework for estimating the impact of environmental influences on human development in the context of an exploratory learning situation.



The prolactin response to sulpiride in major depression: the role of the D2 receptor in depression

The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function

After 16 weeks of cognitive behavioural therapy (CBT), an enhanced prolactin response to sulpiride was detected, suggesting an increased sensitivity of D2 receptor functioning.

A preliminary study of dopamine-mediated prolactin inhibition in generalised social phobia

Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia.

The findings suggest that patients with social phobia may exhibit selective supersensitivity of serotonergic systems, but that dopaminergic and noradrenergic function appear normal.

Striatal dopamine D2 receptor availability in OCD with and without comorbid social anxiety disorder: preliminary findings

Comorbid GSAD and OCD may be associated with decreased availability of D2 receptors in the striatum, consistent with prior findings in GSAD.

Dopamine reuptake site densities in patients with social phobia.

blind quantitative analysis revealed that striatal dopamine reuptake site densities were markedly lower in the patients with social phobia than in the age- and gender-matched comparison subjects.

Low dopamine D(2) receptor binding potential in social phobia.

Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum, and there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score.

Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.

Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets.

The emergence of social phobia during clozapine treatment and its response to fluoxetine augmentation.

Data is discussed in light of neurochemical mechanisms and cognitive adaptations that could explain the onset of anxiety spectrum disorders (such as social phobia) in clozapine-treated schizophrenic subjects during remission of psychotic symptoms.

Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson’s disease

All of the tasks impaired following sulpiride are known to be sensitive to frontal lobe damage and the precise pattern of deficits seen is consistent with the anatomical distribution of central dopamine receptors.