The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism.

@article{Carmena1993TheRT,
  title={The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism.},
  author={Rafael Carmena and Ghislaine O. Roederer and H Mailloux and Suzanne Lussier-Cacan and Jean Davignon},
  journal={Metabolism: clinical and experimental},
  year={1993},
  volume={42 7},
  pages={895-901}
}
In a retrospective study, we examined the influence of apolipoprotein (apo) E polymorphism and gender on the response to treatment with 80 mg/d lovastatin in a homogeneous population of patients with familial hypercholesterolemia (FH), most of whom were carriers of the 10-kb deletion of the low-density lipoprotein (LDL) receptor gene. Apo E phenotype distribution among the 189 FH patients was not different from that of a normal population sample. The total and LDL cholesterol (LDL-C) response… CONTINUE READING

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