The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1

@article{Vester2004TheRT,
  title={The response to cyclophosphamide in steroid-sensitive nephrotic syndrome is influenced by polymorphic expression of glutathion-S-transferases-M1 and -P1},
  author={Udo Vester and Birgitta Kranz and Stephanie Zimmermann and Rainer B{\"u}scher and Peter Friedrich Hoyer},
  journal={Pediatric Nephrology},
  year={2004},
  volume={20},
  pages={478-481}
}
Glutathione-S-transferases (GST) play a central role in the inactivation of toxic drugs like cyclophosphamide (CP). These enzymes depict several polymorphisms with altered activity, and it has been shown that different polymorphisms influence the risk of malignancies and the outcome after chemotherapy. To prove the hypothesis that CP efficacy in children with nephrotic syndrome is influenced by polymorphic expression of GSTs, the genotype of 26 patients was analyzed and correlated with the… CONTINUE READING

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