The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis.

@article{Oyston2000TheRR,
  title={The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis.},
  author={Petra C. F. Oyston and Nick Dorrell and Kevin P. Williams and S. R. Li and Miyoko Green and Richard W. Titball and Brendan W. Wren},
  journal={Infection and immunity},
  year={2000},
  volume={68 6},
  pages={3419-25}
}
The two-component regulatory system PhoPQ has been identified in many bacterial species. However, the role of PhoPQ in regulating virulence gene expression in pathogenic bacteria has been characterized only in Salmonella species. We have identified, cloned, and sequenced PhoP orthologues from Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica. To investigate the role of PhoP in the pathogenicity of Y. pestis, an isogenic phoP mutant was constructed by using a reverse… CONTINUE READING