The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage: gating at the cytoplasmic mouth

@inproceedings{Ashmole2009TheRO,
  title={The response of the tandem pore potassium channel TASK-3 (K2P9.1) to voltage: gating at the cytoplasmic mouth},
  author={Ian Ashmole and Dimitris V. Vavoulis and Phillip J. Stansfeld and Puja R Mehta and Jiafeng Feng and Michael J. Sutcliffe and Peter R. Stanfield},
  booktitle={The Journal of physiology},
  year={2009}
}
Although the tandem pore potassium channel TASK-3 is thought to open and shut at its selectivity filter in response to changes of extracellular pH, it is currently unknown whether the channel also shows gating at its inner, cytoplasmic mouth through movements of membrane helices M2 and M4. We used two electrode voltage clamp and single channel recording to show that TASK-3 responds to voltage in a way that reveals such gating. In wild-type channels, P(open) was very low at negative voltages… CONTINUE READING

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Insight into the mechanisms of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations

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  • Biochemistry
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TASK-3 potassium channels: gating at the cytoplasmic mouth of the channel

  • PR Stanfield, I Ashmole, PJ Stansfeld, MJ Sutcliffe
  • Proc Physiol Soc 11,
  • 2008
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