The response of the subthalamo-pallidal networks of the Basal Ganglia to oscillatory cortical input in Parkinson’s disease

Primary motor symptoms of Parkinson’s disease such as bradykinesia and rigidity are associated with increased oscillatory and synchronized activity in the beta frequency band (10-30Hz) throughout the cortical-basal ganglia-thalamic circuitry (see, for example, [1]). The origin of the pathological beta-band oscillations is not completely understood, however… CONTINUE READING