The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid

@article{Walters2015TheRO,
  title={The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid},
  author={Julian R. F. Walters and Ian M. Johnston and Jonathan D. Nolan and Claire Vassie and Mark Pruzanski and David Shapiro},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2015},
  volume={41}
}
Bile acid diarrhoea is a common cause of chronic diarrhoea, occurring as a primary condition or secondary to ileal disease or resection. Many patients have reduced levels of the ileal hormone fibroblast growth factor 19 (FGF19), an inhibitory regulator of hepatic bile acid synthesis, secreted in response to farnesoid X receptor (FXR) activation. 

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  • M. CamilleriS. Nurko
  • Medicine, Biology
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  • 2021
Advances in diagnosis of BAD provide opportunities for generalists and pediatric and adult gastroenterologists to provide targeted treatment for BAD presenting as chronic non‐bloody diarrhea.

Randomised clinical trial: Significant biochemical and colonic transit effects of the farnesoid X receptor agonist tropifexor in patients with primary bile acid diarrhoea.

Slowing of ascending colon emptying suggests therapeutic potential of tropifexor in patients with primary bile acid diarrhoea and changes in FGF19 and C4 showed effective target engagement; however, higher doses may be required to observe stool frequency changes.

Obeticholic acid for severe bile acid diarrhea with intestinal failure: A case report and review of the literature

A 32-year-old woman with quiescent colonic Crohn’s disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea and fatigue, and third-line treatment with obeticholic acid reduced the number of stools and improved the patient's quality of life.

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

In patients with idiopathic chronic constipation, an increased number of bowel movements was observed and various IBAT inhibitors showed potential to improve itching, and difficulties that should be addressed in future studies are discussed.

Bile Acid Diarrhea

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