The response of human B cells to interleukin 4 is determined by their stage of activation and differentiation.

@article{Maher1990TheRO,
  title={The response of human B cells to interleukin 4 is determined by their stage of activation and differentiation.},
  author={Darryl W. Maher and Beverley L. Pike and Andrew W. Boyd},
  journal={Scandinavian journal of immunology},
  year={1990},
  volume={32 6},
  pages={631-40}
}
The effect of purified recombinant human interleukin 4 (IL-4) on proliferation and IgM secretion of normal and malignant human B cells was studied. IL-4 was found to co-stimulate the proliferation of splenic B cells in the presence of anti-Ig coupled to polyacrylamide beads (anti-Ig beads) for a period of 4 days. In contrast, IL-4 had little co-stimulatory… CONTINUE READING