The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.

@article{Eilers1993TheRO,
  title={The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage.},
  author={Alexander Eilers and Dirk Seegert and C Schindler and M Baccarini and Thomas Decker},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 6},
  pages={
          3245-54
        }
}
Gamma interferon activation factor (GAF) rapidly induces transcriptional activation of gamma interferon (IFN-gamma)-responsive genes. Conversion of the GAF from a latent cytoplasmic to an activated, DNA-binding form is an immediate step in the cellular response to IFN-gamma. The amount of IFN-gamma-activated GAF, measured by exonuclease III protection or gel shift assays, increased strongly upon monocytic differentiation of U937 cells. Activated GAF contained the IFN-responsive 91-kDa protein… CONTINUE READING

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IFNgamma signaling-does it mean JAK-STAT?

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Inteferons pen the JAK-STAT pathway.

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