The response of bone to unloading

  title={The response of bone to unloading},
  author={Daniel D Bikle and Bernard P. Halloran},
  journal={Journal of Bone and Mineral Metabolism},
Skeletal unloading leads to decreased bone formation and decreased bone mass. Bone resorption is uncoupled from bone formation, contributing to the bone loss. During spaceflight bone is lost principally from the bones most loaded in the 1-g environment, and some redistribution of bone from the lower extremities to the head appears to take place. Although changes in calcitropic hormones have been demonstrated during skeletal unloading (PTH and 1,25(OH)2D decrease), it remains unclear whether… CONTINUE READING


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Effects of simulated weightlessness on bone mineral metabolism

  • RK Globus, DD Bikle, E Morey Holton
  • Endocrinology
  • 1984
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