The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat.

@article{Gu2011TheRA,
  title={The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat.},
  author={X. P. Gu and LiangYu Peng and Dong Hee Yang and Qing Ma and Yaguo Zheng and Chenglong Liu and Beibei Zhu and Lihua Song and Xiaofeng Sun and Zhengya Ma},
  journal={Brain research},
  year={2011},
  volume={1396},
  pages={88-95}
}
High levels of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are colocalized in the substantia gelatinosa. This indicates that the pain pathways appear to be under a strong regulation of these receptors. However, their respective effects on pain behaviors and their interaction remain unclear. Here we show that the nociceptive behaviors induced by chronic compression of the lumbar dorsal root ganglion (CCD) are attenuated by either GR agonist dexamethasone (4=2 μg>vehicle) or… CONTINUE READING

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