The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1.

@article{Lima2017TheRO,
  title={The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1.},
  author={K{\'a}tia Manuela Lima and Juliana Priscila Vago and Tha{\'i}s R Caux and Graziele Let{\'i}cia Negreiros-Lima and Michelle A Sugimoto and Luciana P{\'a}dua Tavares and Raquel Gregorio Arribada and Aline A F Carmo and Izabela Baptista Galv{\~a}o and Bruno Rocha C Costa and Frederico M. Soriani and Vanessa Pinho and Egle Solito and Mauro Perretti and Mauro Martins Teixeira and Lirl{\^a}ndia Pires Sousa},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 33},
  pages={
          13758-13773
        }
}
Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects. We have shown previously that the cAMP-enhancing compounds rolipram (ROL; a PDE4 inhibitor) and Bt2cAMP (a cAMP mimetic) drive caspase-dependent resolution of neutrophilic inflammation. In this follow-up study, we investigated whether AnxA1 could be involved in the pro-resolving properties of these compounds using a model of LPS-induced inflammation in BALB/c mice. The treatment… CONTINUE READING
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