The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA.

@article{Venema1990TheRR,
  title={The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA.},
  author={Jaap Venema and Anneke van Hoffen and Adayapalam Tyagarajan Natarajan and Albert A. van Zeeland and L. H. Mullenders},
  journal={Nucleic acids research},
  year={1990},
  volume={18 3},
  pages={443-8}
}
We have measured removal of pyrimidine dimers in defined DNA sequences in confluent and actively growing normal human and xeroderma pigmentosum complementation group C (XP-C) fibroblasts exposed to 10 J/m2 UV-irradiation. In normal fibroblasts 45% and 90% of the dimers are removed from the transcriptionally active adenosine deaminase (ADA) gene within 4 and 24 hours after irradiation respectively. Equal repair efficiencies are found in fragments located entirely within the transcription unit or… CONTINUE READING

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