The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status.

@article{Dvdec2012TheRT,
  title={The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status.},
  author={Sylvia E Le D{\'e}v{\'e}dec and Bart Geverts and Hans J G M de Bont and Kuan Yan and F. J. Verbeek and Adriaan B. Houtsmuller and Bob van de Water},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 19},
  pages={4498-506}
}
Focal adhesions (FAs) are specialized membrane-associated multi-protein complexes that link the cell to the extracellular matrix and enable cell proliferation, survival and motility. Despite the extensive description of the molecular composition of FAs, the complex regulation of FA dynamics is unclear. We have used photobleaching assays of whole cells to determine the protein dynamics in every single focal adhesion. We identified that the focal adhesion proteins FAK and paxillin exist in two… CONTINUE READING
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