The research and development of a 5-HT selective reuptake blocker. Preclinical aspects.

@article{Agurell1983TheRA,
  title={The research and development of a 5-HT selective reuptake blocker. Preclinical aspects.},
  author={St. Agurell},
  journal={Acta psychiatrica Scandinavica. Supplementum},
  year={1983},
  volume={308},
  pages={19-24}
}
  • St. Agurell
  • Published 1983 in Acta psychiatrica Scandinavica. Supplementum
The preclinical development of zimeldine according to the 5-HT (serotonin) hypothesis is briefly reviewed. Zimeldine is a selective 5-HT reuptake inhibitor based on the "chemical lead" of brompheniramine--an antihistamine with some 5-HT reuptake inhibitory properties. By chemical manipulation of the position of the pyridine ring in brompheniramine and the stereochemistry of the side chain, a selective 5-HT reuptake inhibitor has been developed. 

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