The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo

@article{Hunt1992TheRF,
  title={The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo},
  author={Tim Hunt and Francis C. Luca and Joan V. Ruderman},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={116},
  pages={707 - 724}
}
Fertilization of clam oocytes initiates a series of cell divisions, of which the first three--meiosis I, meiosis II, and the first mitotic division--are highly synchronous. After fertilization, protein synthesis is required for the successful completion of every division except meiosis I. When protein synthesis is inhibited, entry into meiosis I and the… CONTINUE READING