The requirement of specific anticapsular IgG for killing of Haemophilus influenzae by the alternative pathway of complement activation.


Employing an in vitro bactericidal assay using C4-deficient guinea pig serum (C4D-GPS), we evaluated the ability of the alternative pathway to kill a number of strains of encapsulated and unencapsulated Haemophilus influenzae (HI). Complement activation occurred, but no bactericidal activity was observed against any of the tested HI in nonimmune C4D-GPS… (More)


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