The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.

@article{Michalek2007TheRO,
  title={The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.},
  author={Ryan D. Michalek and Kimberly J. Nelson and Beth C. Holbrook and John S. Yi and Daya Stridiron and Larry W. Daniel and Jacquelyn S Fetrow and S Bruce King and Leslie B. Poole and Jason M. Grayson},
  journal={Journal of immunology},
  year={2007},
  volume={179 10},
  pages={6456-67}
}
Reactive oxygen intermediates (ROI) generated in response to receptor stimulation play an important role in mediating cellular responses. We have examined the importance of reversible cysteine sulfenic acid formation in naive CD8(+) T cell activation and proliferation. We observed that, within minutes of T cell activation, naive CD8(+) T cells increased ROI levels in a manner dependent upon Ag concentration. Increased ROI resulted in elevated levels of cysteine sulfenic acid in the total… CONTINUE READING
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