The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11)

@article{Schwartz1976TheRF,
  title={The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11)},
  author={Ronald H. Schwartz and M. E. Dorf and Baruj Benacerraf and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  journal={The Journal of Experimental Medicine},
  year={1976},
  volume={143},
  pages={897 - 905}
}
The antibody response to poly-(Glu53Lys36Phe11) (GLphi) has been shown to be under the control of two independent, major histocompatibility-linked immune response genes, designated alpha and beta. In the present work we demonstrate that the T-lymphocyte proliferative response is also under the control of these two immune response genes. Thus, mice of the H-2a, H-2b, H-2k, and H-2s haplotypes were all nonresponders to GLphi. In contrast F1 hybrids between these strains, such as (B10 X B10.A)F1… CONTINUE READING

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