The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.

@article{Silver1999TheRF,
  title={The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.},
  author={Phyllis B. Silver and Chi Chao Chan and Barbara N Wiggert and Rachel R Caspi},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 12},
  pages={2898-905}
}
PURPOSE Experimental autoimmune uveoretinitis (EAU) in mice is an important model for elucidating basic mechanisms in autoimmune eye disease. The need for pertussis toxin (PTX) as an additional adjuvant to elicit EAU has limited the usefulness of this model in some types of studies by introducing a pleiotropic factor with confounding effects on the immune response. METHODS In the present study the authors examined the ability of B10.RIII mice, the most susceptible strain known so far, to… CONTINUE READING