The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.

@article{Matreyek2011TheRF,
  title={The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.},
  author={Kenneth A. Matreyek and Alan N. Engelman},
  journal={Journal of virology},
  year={2011},
  volume={85 15},
  pages={7818-27}
}
Lentiviruses likely infect nondividing cells by commandeering host nuclear transport factors to facilitate the passage of their preintegration complexes (PICs) through nuclear pore complexes (NPCs) within nuclear envelopes. Genome-wide small interfering RNA screens previously identified karyopherin β transportin-3 (TNPO3) and NPC component nucleoporin 153 (NUP153) as being important for infection by human immunodeficiency virus type 1 (HIV-1). The knockdown of either protein significantly… CONTINUE READING