The disposable soma theory revisited: Time as a resource in the theories of aging
- BiologyCell cycle
It is suggested that the ability to devote longer periods of time to repair and maintenance is a key feature of longer-lived species, and that evolutionary pressure to complete repair and resume cell division is a determinant of species lifespan.
Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?
- BiologyMedical hypotheses
The interconnections between somatic and ovarian aging in murine models.
- BiologyThe journals of gerontology. Series A, Biological sciences and medical sciences
Delaying ovarian aging will not only increase the fertility window of middle age females, but may also actively prevent menopausal-related decline in systemic health parameters, compressing the period of morbidity in mid-to-late life in females.
A New Look At the Origin of the Immune System and NewImmune Theory of Aging: Lymphocyte Regulation of CellularGrowth of Somatic Tissues: (History and Modern Concepts)
This work has proposed a theory of self-organizing “cellular hyper cycle” based on the general theory of hyper cycle, which isbased on the evident inevitability of the generation during evolution of higher order regulatory relations between selfreplicating units and systems of lower order.
Hypothalamic–pituitary–gonadal axis homeostasis predicts longevity
- Medicine, BiologyAGE
The relationship between longevity and menopause, including other factors that impact “ovarian lifespan” such as births, oophorectomy, and hormone replacement therapy, is analyzed to support the maintenance of the hypothalamic–pituitary–gonadal axis in homeostasis in prolonging human longevity.
Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species
It is suggested that organisms with greater reproductive endocrine dyscrasia more rapidly undergo senescence and die, and the contribution post-reproduction by non-gonadal tissues to circulating sex hormones dictates post- reproductive tissue health and longevity.
Human Embryonic Stem Cells: A Model System for Delineating the Molecular Basis of Human Embryogenesis and Aging-related Diseases
The potential for using hESC, embryoid bodies (EBs) and neuroectodermal rosettes to gain insights into how reproductive endocrine dyscrasia associated with menopause/andropause drives aberrant cell cycle signalling mechanisms leading to age-related diseases including neurodegeneration and associated cognitive decline is described.
Hormones of Hypothalamus in Aging
- Biology, Medicine
Various hormonal changes that occur with age in hypothalamus and pituitary gland are discussed and how these two master regulators gradually lose their sensitivity with the increasing age is discussed.
"Lymphocyte Regulation of Cellular Growth of Somatic Tissues: A New Look at the Origin of the Immune System and New Immune Theory of Aging (History and Modern Concepts)"
This work has proposed a theory of selforganizing “cellular hypercycle” based on the general theory of hypercycle, a concept of intrinsic self-organization that determines the integration and coordinated evolution of a system of functionally related self-replicating units.
Identification of Late Larval Stage Developmental Checkpoints in Caenorhabditis elegans Regulated by Insulin/IGF and Steroid Hormone Signaling Pathways
- BiologyPLoS genetics
It is shown here that specific checkpoints exist in the early L3 and early L4 stages that systemically arrest the development of diverse tissues and cellular processes and identify a novel mode of C. elegans growth in which development progresses from one checkpoint to the next.
SHOWING 1-10 OF 102 REFERENCES
Signals from the reproductive system regulate the lifespan of C. elegans
The C. elegans insulin/IGF-1 system integrates multiple signals to define the animal's rate of ageing, and this study demonstrates an inherent relationship between the reproductive state of this animal and its lifespan, and may have implications for the co-evolution of reproductive capability and longevity.
Living and Dying for Sex
It is proposed that the hormones that regulate reproduction act in an antagonistic pleiotrophic manner to control aging via cell cycle signaling; promoting growth and development early in life in order to achieve reproduction, but later in life, in a futile attempt to maintain reproduction, become dysregulated and drive senescence.
Are reproductive and somatic senescence coupled in humans? Late, but not early, reproduction correlated with longevity in historical Sami women
- Biology, PsychologyProceedings of the Royal Society B: Biological Sciences
The results suggest that reproductive and somatic senescence may have been coupled in these human populations, and that selection could have favoured late reproduction in historical post-reproductive Sami women.
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans
The germ line of the nematode Caenorhabditis elegans Influences life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.
Neural cell cycle dysregulation and central nervous system diseases
- BiologyProgress in Neurobiology
No extension of lifespan by ablation of germ line in Drosophila
- BiologyProceedings of the Royal Society B: Biological Sciences
It is found that germ line ablated females had reduced longevity relative to controls and that the removal of the germ line led to an over-proliferation of the somatic stem cells in the germarium, contrasting with the widely held view that it is downstream reproductive processes such as the production and/or laying of eggs that are costly to females.
Sex steroids and growth factors in the regulation of mammary gland proliferation, differentiation, and involution
Cancer genesis across the age spectrum: associations with tissue development, maintenance, and senescence.
- Medicine, BiologySeminars in radiation oncology
Dysregulation of the Hypothalamic-Pituitary-Gonadal Axis with Menopause and Andropause Promotes Neurodegenerative Senescence
- Biology, MedicineJournal of neuropathology and experimental neurology
It is proposed that dysregulated HPG hormone signaling with menopause/andropause leads to the abortive reentry of differentiated neurons into the cell cycle via a process the authors term "dyosis," which results in a hormonal milieu that is permissive of cell cycle reentry but does not allow completion of metaphase.
Reproductive hormones regulate the selective permeability of the blood-brain barrier.
- BiologyBiochimica et biophysica acta