The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.

@article{Scott1998TheRO,
  title={The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.},
  author={Donald K Scott and Robert Martin O'Doherty and John M. Stafford and Christopher B. Newgard and Daryl K. Granner},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 37},
  pages={24145-51}
}
Phosphoenolpyruvate carboxykinase (PEPCK) is a rate-controlling enzyme in hepatic gluconeogenesis, and it therefore plays a central role in glucose homeostasis. The rate of transcription of the PEPCK gene is increased by glucagon (via cAMP) and glucocorticoids and is inhibited by insulin. Under certain circumstances glucose also decreases PEPCK gene expression, but the mechanism of this effect is poorly understood. The glucose-mediated stimulation of a number of glycolytic and lipogenic genes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…