The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.

@article{Perfetti2012TheRO,
  title={The repertoire of $\lambda$ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44.},
  author={Vittorio Perfetti and Giovanni Palladini and Simona Casarini and Valentina Navazza and Paola Rognoni and Laura Obici and Rosangela Invernizzi and Stefano Perlini and Catherine Klersy and Giampaolo Merlini},
  journal={Blood},
  year={2012},
  volume={119 1},
  pages={
          144-50
        }
}
Monoclonal Ig light chains (LC) can be responsible for pathologic conditions in humans, as in systemic amyloid light amyloidosis. Protean clinical manifestations characterize this disorder with the most varied combination of symptoms generated by different degrees of diverse organ involvement. Kidney and heart are most frequently interested, with major heart involvement as the most relevant prognostic factor. The identification of the underlying mechanism involved in organ targeting is of major… 
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[AL amyloidosis].
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