The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis.

@article{McGlinchey2009TheRD,
  title={The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis.},
  author={Ryan P. McGlinchey and Frank Shewmaker and P Mcphie and Bego{\~n}a Monterroso and Kent R. Thurber and Reed B Wickner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 33},
  pages={13731-6}
}
Pmel17 is a melanocyte protein necessary for eumelanin deposition 1 in mammals and found in melanosomes in a filamentous form. The luminal part of human Pmel17 includes a region (RPT) with 10 copies of a partial repeat sequence, pt.e.gttp.qv., known to be essential in vivo for filament formation. We show that this RPT region readily forms amyloid in vitro, but only under the mildly acidic conditions typical of the lysosome-like melanosome lumen, and the filaments quickly become soluble at… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Characterization of -sheet structure in Ure2p1–89 yeast prion fibrils by solid state nuclear magnetic resonance

  • U Baxa
  • Biochemistry
  • 2007

Similar Papers

Loading similar papers…