The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation.

@article{Ogawa2006TheRE,
  title={The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation.},
  author={Fumihide Ogawa and Christina S Sander and Alfred Hansel and Wolf Oehrl and Hubert Kasperczyk and Peter Elsner and Kazuhiro Shimizu and Stefan H. Heinemann and Jens J Thiele},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 5},
  pages={1128-34}
}
Recently, we reported that photoaging correlates well with the amount of oxidized protein accumulated in the upper dermis, while protein oxidation levels in the viable epidermis are very low. We hypothesized that this might be due to epidermal expression of the repair enzymes methionine sulfoxide reductases (MSRs). The expression of human methionine sulfoxide reductase A (MSRA) was investigated in HaCaT cells, primary human keratinocytes, and in human skin. High MSRA mRNA and protein levels as… CONTINUE READING

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