The renin-angiotensin system in the heart and vascular wall: new therapeutic aspects.

@article{Falkenhahn1994TheRS,
  title={The renin-angiotensin system in the heart and vascular wall: new therapeutic aspects.},
  author={Mechthild Falkenhahn and Peter Gohlke and Martin Paul and Monika Stoll and Thomas Unger},
  journal={Journal of cardiovascular pharmacology},
  year={1994},
  volume={24 Suppl 2},
  pages={S6-13}
}
Traditionally, the renin-angiotensin system (RAS) has been viewed as an endocrine system. Recently, independent tissue RASs have been postulated that are believed to act in a paracrine/autocrine fashion. Elements of the RAS have been shown to exist in many peripheral tissues. Angiotensin-converting enzyme (ACE), a key element of the RAS, is found mainly in the vascular endothelium and therefore represents the main target site for inhibition of the local and circulating RASs. In the heart… CONTINUE READING

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